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FMSE — Fluctuating Mental Status Evaluation

2023

A five-domain neurocritical-care screen that rates fluctuation from an established post-injury cognitive baseline. It is designed to reduce confounding from fixed focal deficits such as aphasia.

Monitoring / repeated screeningIntensive careMultiple DTA studies identifiedCore instrument family

What this tool is and how to interpret its evidence

Published in 2023, FMSE is described here as monitoring / repeated screening, intensive care for adults with intracerebral haemorrhage / neurocritical illness. The linked study examined it in Intensive care. The recorded form contains 5 scored items or observations. The reported administration time is approximately 1 min after relevant observations are available. The catalogue records the published scoring or threshold information as 1 or more indicates possible delirium; 2 or more indicates probable delirium in published neurocritical-care studies.

The linked source is Reznik ME and colleagues, A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients in Neurocritical care (2023); this catalogue treats it as original/source and earliest DTA study. For FMSE, the evidence stage is multiple eligible diagnostic-accuracy studies. The reconciled DTA dataset associates 2 eligible studies with FMSE. The earliest listed evaluation used Expert DSM-5 delirium ratings as its reference standard. The first recorded accuracy result reports sensitivity 86% and specificity 73%; the recorded sample is 40.

Repeated FMSE observation may capture fluctuation, but interpretation depends on when and how observations are collected. Arousal, sedation and communication constraints are relevant when interpreting an intensive-care assessment. For FMSE, no verified public instrument form is recorded; the source article documents the tool but is not a substitute administration form.

Evidence and practical details

86%
Sensitivity*
73%
Specificity*
n=40
Sample
Full name
Fluctuating Mental Status Evaluation
Also known as
FMSE
Catalogue class
Core instrument family
Record type
core-family
Family
fmse
Purpose
Monitoring / repeated screening, Intensive care
Population
Adult
Setting
Intensive care
Items
5
Administration
approximately 1 min after relevant observations are available
Evidence
Multiple DTA studies identified
Evidence maturity
external-validation
Evidence stage
diagnostic-accuracy-multiple-studies
DTA studies identified
2
Current audit status
provisional DTA identified
Reference type
Original/source and earliest DTA study
Reference standard
Expert DSM-5 delirium ratings
Validation sample
n = 40
Cut-off / scoring
1 or more indicates possible delirium; 2 or more indicates probable delirium in published neurocritical-care studies
Original/source citation
Reznik ME, Margolis SA, Moody S, Drake J, Tremont G, Furie KL, Mayer SA, Ely EW, Jones RN A Pilot Study of the Fluctuating Mental Status Evaluation: A Novel Delirium Screening Tool for Neurocritical Care Patients Neurocritical care. 2023;38(2):388-394. PMID 36241773

Format and clearly labelled links

Five binary domain ratings summarise changes in consciousness, orientation, activity, thought content and attention over a defined observation period. The 0-5 total depends on establishing an appropriate neurological baseline; use the source for the rating instructions.

Rights, version and permission record

Instrument access state
No verified public instrument form
Instrument host
No verified instrument host
Current instrument/version note
No version verified
Rights holder
Not yet verified
Licence / rights basis
No licence verified
Rights checked
2026-07-19
Rights-holder contact
Not yet verified

Permission scope recorded at the last check

  • Clinical use: Not verified; obtain the current authorised instrument and follow its terms.
  • Research use: Not verified; check with the developer or rights holder.
  • Web republication: Not verified; do not reproduce the form or item wording.
  • Translation/adaptation: Not verified; written permission may be required.
  • EHR/software integration: Not verified; check before implementation.
  • Commercial use: Not verified; check before use.

Site-text licence boundary: the CC BY 4.0 notice for original deliriumtools.com editorial text does not cover third-party instruments, item wording, forms, article text, logos, screenshots or linked material.

Page record and review status

Page version
3.1.0
Last factual/source check
2026-07-19
Last rights/link check
2026-07-19
Curator and responsible editor
Professor Alasdair M J MacLullich — Curator factual and source review complete (not an independent external reviewer)
Independent external clinical review
Not yet completed. No independent external reviewer, consortium endorsement or institutional endorsement is claimed.

Corrections and rights-holder notices can be submitted through the contribute and corrections page.

* Where shown, sensitivity/specificity are from the cited evaluation and are not pooled estimates. “DTA studies identified” describes the current audit, not a completed systematic-review count. Citation metadata checked against PubMed or a publisher record does not imply validation, study quality, endorsement or suitability for a setting. See Methodology.